The Parkinson’s disease also called Morbus Parkinson (other synonym: Idiopathic Parkinson-Syndrome (IPS), lat: Paralysis agitans) is a slowly progressing degenerative cerebral disease. It belongs to the degenerative diseases of the extra pyramidal (motor) system. The Morbus Parkinson is characterised by a principally dying of the nerve cells within the Substantia nigra – a structure in the midbrain with the transmitter dopamine. The lack of dopamine ultimately leeds to a reduction of the activating influence of the basal ganglia onto the cerebral cortex.

The current definition of the Parkinson-Syndrome demands the key symptom Brady respectively Akinesia in combination with at least one cardinal symptom Rigor, rest tremor and unstable posture (postural instability). In addition different sensible, vegetative, mental and cognitive disorders are possible.

Current rTMS-studies concerning Parkinson’s disease:

• Treatment of articulatory dysfunction in Parkinsons´s disease using repetitive transcranial magnetic stimulation
• Slow (1Hz) repetitive transcranial magnetic stimulation (rTMS) induces a sustained change in cortical excitability in patients with Parkinsons´s disease
• Scientific grant at Beth Israel Deaconess Medical Center, USA, for research concerning rTMS in Parkinson´s disease 
• The impact of left prefrontal repetitive transcranial magnetic stimulation on depression in Parkinson´s disease: A randomized, double-blind, placebo-controlled study